Is loratadine the best antihistamine out there?

Depends: the best one is the one that works best for you without giving you side effects. Different people respond differently, so see what works best for you.

Not Claritin (loratadine) Clear?: Hi, Member837. Loratadine is safe, effective (versus placebo), and rated as "non-sedating" (though I've had some say they get sleepy). Used to be prescription only, but direct studies comparing it to fexofenadine and cetirizine showed it was slower and less effective. Of course, diphenhydramine (Benadryl) is stronger. The best? Depends. Does it work for you?

Which one works: the best for you is the best one for you.