A member asked:

Would you get cancer from monoclonal antibodies?

4 doctors weighed in across 2 answers

No: Monoclonals antibodies are forms of gamma globulin made by a cell type noted as hybridoma which is a fused benign B cell with a malignant B cell, producing one clone of antibody in perpetuity The gamma globulins if specific for a known tumor protein, hunt see and destroy the tumor by a mechanism known as ADCC and do not accomplish the reverse, that is induce malignancy.

Answered 1/27/2015

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Dr. Le Wang answered

Specializes in Internal Medicine

Not directly, but: Not directly. But certain monoclonal antibody such as ab to tnf, etc, can result in a profound immune suppression state, which then increases the risk of secondary cancer. We see this in clinical practice.

Answered 5/2/2014

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