My girlfriend is constantly down emotionally because of acne. should we get accutane?

Yes: Acne can cause depression, and Accutane can be miraculous for many people with acne that doesn't respond to other treatment. As long as your girlfriend is on two different forms of birth control for at least a month before starting accutane, and continuing until at least a month after the end of treatment, Accutane might be a good choice for her.