Should i be taking progesterone if i am taking premarin, (conjugated estrogens) and am pre-menopausal?

Depends: Not if you're having regular menses. Your doctor may prescribe Progesterone to induce periods, or lo-dose daily therapy to prevent them -- some physicians would not want you to receive either. But these are questions that need to be discussed with your doctor.

Dr Samuel agreed

Progesterone: It depends on what your levels are. It is unusual to be giving a pre-menopausal woman estrogen without progesterone. In general, progesterone levels decrease prior to estrogen levels. The vast majority of my peri-menopausal patients start progesterone years before they start estrogen. Also be aware that premarin (conjugated estrogens) is horse estroen , not human estrogen. Since you are not a horse, you may not want to