Are there any side effects of taking flonase?

Local issues: Biggest side effect is nasal inflammation and bleeding. To minimize this, when you put the sprayer in your nose angle the tip to the outside corner of your eye. This will direct the spray away from your septum and decrease irritation.

Yes: There are several, but the most common one is epistaxis, or nosebleeds. Some people may experience headaches nasal burning, or cough. Since it is topical, very little is actually absorbed into the body.