A member asked:

I'm taking venlafaxine is it ok to take passion flower kava kava and skullcap herbs are there any adverse reaction?

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Dr. Pamela Pappas answered

Specializes in Psychiatry

Herbs & venlafaxine: You've asked this question several times earlier, and are now adding kava to your brew. There's a slight interaction between kava & venlafaxine, but not with passion flower or skullcap. Kava is more sedating than skullcap or passion flower too. I still wonder why you want to add these herbs to your effexor? Please discuss w/your doctor before taking them, especially if Effexor isn't helping u.

Answered 7/15/2017

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Can't be sure.: Too potentially complicated and insufficient evidence in the literature to gauge. There are reports of kava kava toxicity with kava kava alone. So it seems it should be left on the shelf. Since there is no good evidence of benefit with skullcap probably shouldn't take that either. Passion flower doesn't have any glaring warnings, but also little evidence that it works.

Answered 3/24/2013

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