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A 41-year-old female asked:

Is treatment necessary for systemic mastocytosis? i am taking gleevec (imatinib). what would happen if i stopped taking it?

1 doctor answer3 doctors weighed in
Dr. Liawaty Ho
Hematology and Oncology 24 years experience
D/w oncologist: There are indolent systemic masto, and agressive systemic mastocytosis (asm). Many times, with indolent disease- therapy will be aimed only to control the symptoms- itching, diarrhea etc. If you have an asm- then usually treatment is started. Asm can manifest from slowly progressive to rapid fatal disease.Organ involvement , transformation to other blood DX including acute leukemia can happen.
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Dr. Liawaty Ho
Dr. Liawaty Ho commented
Hematology and Oncology 24 years experience
Provided original answer
your doctor should rule out certain mutation that is related to resistancy to gleevec. if the SM is resistant to gleevec then your doctor need to consider other option if he/she thinks you need to be on therapy. If you have ASM and you are doing well on therapy and you stop therapy then disease will progress and you can become symptomatic again etc.
Mar 21, 2013

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Last updated Jun 10, 2014

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