I am narcoleptic and on 50mg vyvanse (lisdexamfetamine) with 20 mg dex booster (when needed.)it helps great and with my depression (apathy), but sometimes not at all. y?

Difficult to say: You need to go back to your doctor. Only a precise description of your daily habit of food & beverage intake may cause a difference of effect. Your sleep & physical activity also need to be monitored. Regularity is very important to maintain 4 our health & sometimes it is challenging to sleep, eat healthy & exercise regularly.. Sorry not to b able 2 help more & best wishes to you!