Yes it is possible.: Though rare, there have been reported cases of insomnia (sleep problems ) , restlessness and agitation with use of diphenhyramine (benadryl).Common side effects include, constipation/diarrhea/ drowsy/headache report these to your doctor as soon as possible, confused, agitated, nervous, irregular or fast heartbeat, tremor, trouble passing urine. Please see doctor for proper diagnosis and care.
Answered 12/9/2015
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