Are there any drug interactions i should know about between wellbutrin (bupropion) xl 300mg and 800 mg ibuprofen?

No: These two medications are safe to take together--so long as each is safe for you alone.

A valuable resource: You can use a drug interaction checker whenever you have questions about drug-drug interactions or drug - food interactions. Here is one option (Drugs.Com): https://www.drugs.com/drug_interactions.php Your pharmacist is also an excellent source of information.