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A member asked:
Is vyvanse (lisdexamfetamine) effected by urine alkalinity?
A doctor has provided 1 answer
Excretion is: The percent of dose excreted as unchanged drug varies greatly depending upon urinary ph and urine flow. At low ph as much as 70% of the dose may be excreted as amphetamine in 24 h, whereas as little as 1% may be excreted within 24 h at alkaline ph (j. Pharm. Pharmacol. 21:241-258 (1969).
Answered 12/9/2013
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