Can coffee give liver pain?

Shouldn't . . .: Coffee shouldn't affect your liver (unless you're mixing it w/irish whiskey or some other alcohol). If you're mixing a lot of cream into your coffee, the fat in the cream may be aggravating your gallbladder. Best way to figure out what's causing "liver pain" is to stop the coffee for a while & see how you feel. Then start it again & see if it comes back. Perhaps you have gastritis? Go see your doc.