What organs/tissues are affected by adenocarcinoma?

Glands.: Adenocarcinomas arise from glandular tissue and are the most common type of malignancy. Common sites include lung, breast, prostate, esophagus, stomach, intestines and pancreas. Patterns of spread vary with site of origin, but metastases to lungs, liver, lymph nodes and bone are typical for adenocarcinomas.

Almost all of them: From top to bottom, here is a sample: salivary glands, thyroid, lungs, esophagus, stomach, breast(s), pancreas, intestines, biliary system, ovaries and peritoneum, prostate, uterus, adrenal glands, other glands, skin glands. Secondarily advanced adenocarcinoma from any origin may spread to other locations too: brain, liver, lungs, bone, skin, lymph nodes.