When i haven't taken my zoloft (sertraline) in 2 + days (rarely happens that i skip) why does it cause me headaches?

Withdrawal symptom: When you miss your zoloft (sertraline) dose, you could be experiencing some withdrawal (or what the drug companies call "discontinuation") effects -- which can include headache. I'm glad you rarely skip your doses for 2+ days.

Discontinuation ?: When you stop taking zoloft (sertraline) it can cause discontinuation symptoms. For some people it can occur more rapidly then others. My patients tell me that they feel a bit like road kill when that happens. Take care.