Can i take cefuroxime (500 mg) with ranitidine?

Should be: Ok. Maybe spread them out a bit in case the low acid situation decreases the absorption of the antibiotic.

Reduce effectiveness: Ranitidine has been show to reduce the Cefuroxime levels when taken together.This may result in antibiotic failure. If you must use ranitidine, take Cefuroxime at least 2 hours before your ranitidine dose.Peak level of Cefuroxime ~2 hours after an oral dose allow 8-12hr before next dose(ranitidine out of body) some side effects diarrhea, heartburn. See you doctor if your symptoms persist/worsen.