What is the currently the best treatment for sickle cell anemia acute chest syndrome?

Multiple treatments.: Management includes macrolide antibiotics (such as azithromycin), supplemental oxygen, modest hydration and often simple transfusion. In addition, good respiratory toilet (chest physiotherapy, incentive spirometry) and pain management is key. It is essential that patients with acute chest are closely monitored, since this syndrome can rapidly deteriorate (exchange transfusion may be needed).

Hospitalization: Acute chest syndrome(acs) in sickle cell disease is a very serious complication and can be fatal. Generally, acs will require hospitalization of the patient and a long period of observation with supportive care. The best treatments are prompt diagnosis and recognition, IV hydration, broad spectrum antiobitics, oxygen, if necessary an exchange or simple transfusion.