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A 29-year-old female asked:

I put on 15lbs on depakote 250. i barely eat and i exercise but nothing changes. will i lose the weight if my dosage is cut in half?

1 doctor answer1 doctor weighed in
Dr. Bennett Machanic
Neurology 53 years experience
Perhaps not: The weight gain with Depakote may well be associated with an idiosyncratic response which is not dose related. Not unusual to gain weight rapidly, and far more difficult to lose it once gained. Since I am unaware of why the drug is being used for you, i cannot comment on alternatives, but young females, who get pregnant run risk of babies having mental retardation or spinal bifida on depakote.
Last updated Jul 1, 2017

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