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A 29-year-old female asked:

Can you take topomax with depakote for mood disorders?

2 doctor answers2 doctors weighed in
Dr. Bennett Machanic
Neurology 54 years experience
Yes,but: The two meds have been used together for numerous epileptic patients, and have minimal drug-drug interactions, and Depakote blood levels can guide dosing. Side effect profile is biggest issue. Topamax: memory and speech, kidney stones, narrow angle glaucoma, metabolic acidosis. Depakote: weight gain(maybe mitigated by topamax), hair loss, tremors, ovarian cysts, pancreatitis, osteoporosis, etc.
Created for people with ongoing healthcare needs but benefits everyone.
Dr. Alan Ali
Dr. Alan Alianswered
Psychiatry 34 years experience
Topamax/Depakote: If doses are therapeutic & monitored by your doc., no significant adverse interactions exist. At high doses, some alteration in potency of both might occur but is insignificant.
Created for people with ongoing healthcare needs but benefits everyone.
Last updated Aug 8, 2017

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