It is an uncommon: Type, always associated with tobacco, characteristic cellular appearance of dominant hyperchromatic nuclei, no nucleolus, scant cytoplasm. Stains with chromogranin, synaptophysin, molecular loss of rb, over production of bcl-2. It responds to chemo, but needs XRT in limited. Goes to many organs early. Need at least chemo and XRT doc to assess.
Answered 2/1/2017
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Agree: Dr. Andrew turrisi is the world's leading expert on this topic. Can't say much more.
Answered 1/16/2013
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