A member asked:

Is pvl genetic, how can i test to make sure that my kids in the future do not get it?

4 doctors weighed in across 3 answers

No, not genetic: Pvl or periventricular leukomalacia is an injury to the white matter of the brain. It usually occurs in preterm infants and occasionally in the fetus. It can result in possible cerebral palsy, motor developmental delays, seizures and vision problems, depending on the severity of the pvl. The extreme preterm infant 24 to 30 weeks are most at risk due to risk of bleeding in the brain.

Answered 11/24/2011

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PVL: Periventricular leukomalacia is white matter damage in the area next to the ventricles. It is caused by low blood flow to the area in the perinatal time period. It is not catchable, but is a consequence of damage, usually in premature infants.

Answered 8/11/2013

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Dr. Johanna Fricke answered

Specializes in Pediatrics - Developmental and Behavioral

PVL is caused by : decreased flow of blood & oxygen to the white matter of the fetal brain that surrounds the ventricles, an area susceptible to damage late in 2nd trimester, so seen more in VLBW infants. Maternal, placental or fetal causes exist, some genetic accidents & inherited disorders, e.g., mitochondrial disorders. A Chromosomal Microarray on affected baby & genetic family history can give you some info.

Answered 9/29/2016

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