What are disadvantages of a heart transplant?

Immunosuppression: Perhaps the biggest disadvantage of heart transplantation is the requirement for immunosuppression and the yearly surveillance with right heart catheterization and biopsies. However, when a patient qualifies for the transplant, their need for it outweighs the above mentioned disadvantages.

Immunosuppression: You will need major surgery, and then be treated with immunosuppressive drugs for the rest of your life. While these drugs can prevent rejection of the heart, they make the recipient more vulnerable to infections and some cancers. However, if one is in end stage heart failure there are few alternatives. Even so, there are not enough donor hearts available for all that need one.