What factors in the body affect the cardiac output?

Many factors: Congenital heart disease, vitamin b1 defiency, anemia, thyroid problem, renal disease, liver disease, brain disease, vascular disease, blood disease, atherosclerosis, valve disease - these are the biggest influencers of cardiac output.

Cardiac output: Stroke volume times heart rate equals cardiac output. Stroke volume relates to myocardial contractility, vascular resistance, vascular volume, anemia and metabolic state. There are subcomponents to all of these.