Very Common: Depo-provera is very effective but notorious for causing abnormal bleeding. Up to 80% irregular bleeding with the first shot. However, it also causes light or absent bleeding (amenorrhea) with subsequent doses. Up to 50% stop menses after their second shot. So if it's your first dose, hang in there. Transient hair loss, weight gain, and depression are also common symptoms you should look for.
Answered 3/14/2019
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