Is there variability in how severe sickle cell can be?

Variable Sickle Cell: Sickle cell disease can be incredibly variable from patient-to-patient. Current research is attempting to understand these differences. Some people with sickle cell disease require frequent hospitalization for pain crisis, while others have never been hospitalized in their life. It is important, however, to go to a physician who specializes in sickle cell disease in order to get the care you need.