How do i remove a painful foot blister?

Don't deroof it. : You don't want to deroof a blister. You can pop it, using a clean instrument, but if you're concerned (if the fluid is an unusual color, or if the surrounding skin is very red and swollen, or the blister is quite large, etc.), you may want to have your health care professional evacuate the blister for you. Keep it clean and dry as it heals.