Is it safe to fly if you're recovering from a talus fracture?

Generally yes but...: Flying after a talus fracture presents a couple of problems. The decreased atmospheric pressure in the cabin relative ground-level pressure will cause your ankle to swell. This can exacerbate pain and/or lead to wound problems. The second issue is blood clot formation. These are more likely in airline travelers. I would speak to your orthopedic surgeon to address these issues.