Can you have leg artery bypass surgery more than once?

Yes: Artery bypass refers to a tube ( natural such as vein or artificial such as ptfe ) with one end sewn to the artery upstream from the blockage and the other end downstream from the blockage. Since atherosclerosis is progressive as is diabetes, bypasses sewn further down the artery may be needed to relieve symptoms and to prevent major amputation.

Yes: Revascularization is common due to the progressive nature of peripheral vascular disease. After an original bypass, scar tissue or intimal hyperplasia forms at the proximal and distal ends of the pipe limiting flow. Ultimately this scarring may shut the bypass down requiring a "new" one. However, as the disease progresses options for further bypasses may become more limited.