A member asked:

My serum b 12 is over 1200; eosinophils elevated; and i have polyneuropathy in my feet. what could cause these conflicting symptoms?

3 doctors weighed in across 2 answers

Not B12-related: Fortunately there isn't B12 toxicity but high B12 levels can competitively interfere with Folic Acid metabolism, so check Folic Acid level. Eosinophilia suggests allergy & autoimmune diseases as well as multiple myeloma; the latter 2 can cause polyneuropathy. Best bet for evaluation would be immunologist and/or hematologist but see a neurologist for neuropathy monitoring.

Answered 4/1/2019

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Maybe something else: Polyneuropathy can be a result of many diseases/conditions, such as anemia, diabetes, inflammatory arthritis, thyroid issues, among many others. Sometimes no specific cause is identifiable, and is known as idiopathic neuropathy.

Answered 10/31/2012

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