Can one take zofran (ondansetron) 4mg one hour apart?

Yes: Yes you can but not to be taken more than a couple of times per day. The better option is finding out the root cause for your nausea and correcting that so that you no longer need the zofran (ondansetron).

Can't be Answered: Though individuals undergoing chemotherapy can take 24 mg before treatments, most people should not exceed 4 mg every 8 hours. Those with liver compromise metabolize drugs at a far slower rate and, therefore, need to be far more cautious about dosing frequency. Guidelines should come directly from your personal physician.