Is vaginal cancer genetic?

Mostly due to HPV: Most vaginal cancers are not related to any inherited genetic risk but instead are due to the sexually transmitted human papilloma virus (hpv). The same high-risk types that cause cervical cancer and precancerous changes can have the same effect on the vagina, vulva, and anus.

No, but...: A certain type of vaginal cancer has a high risk of occurring in a woman if her mother took DES while she was pregnant. This is called clear cell vaginal carcinoma. Women whose mothers took DES have a 40x increased chance of getting this cancer. Early age at first intercourse, smoking, and hpv infection are associated with an increased risk of any type of vaginal cancer.