In stage 4 ovarian cancer, what does it usually mean if your ca-125 goes from 600 to 222 then back up to 350?

Some response: If therapies are changed we look at the ca125 levels to guide the choice of chemotherapy. This would be compatible with a temporary response to type of therapy.

CA 125: The most important prognostic factor in women with ovarian cancer is the extent and completeness of the initial debulking surgery before chemotherapy. Every patient's ca 125's are different and they are very variable. If on treatment, it is standard not to change chemotherapies unless the ca 125 doubles from the level it was at when the current chemo was started.