A member asked:

Can tylenol (acetaminophen) pm cause you to get anxious?

5 doctors weighed in across 2 answers

Yes: Tylenol (acetaminophen) pm contains Diphenhydramine that typically is used for its sedating effects but is also well known to have an idiosyncratic reaction in some that causes them to become anxious.

Answered 6/25/2014

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Yes: Tylenol (acetaminophen) pm contains the same medicine that is in benadryl. Some people have a paradoxical reaction where they become more anxious instead of sleepy.

Answered 4/8/2020

5.5k views

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