Is there an immune system build up after discontinuing humira (adalimumab)?

Humira (adalimumab): The body makes tnf- Alpha as one of the proteins involved in systemic inflammation. When any tnf blocker is stopped inflammation will usually increase and the levels of many cytokines that are involved in inflammation increase as the systemic inflammation increases but tnf is only one protein that increases with increases in inflammation. There is not a build up.

Build Up??: Difficult to answer. Humira (adalimumab) does cause suppression of the immune system to help fight the autoimmune disease, so stopping will hopefully lead to an increase immune response, but on the flip side could also cause a worsening in the autoimmune disease.