See below: Migraines may be caused by changes in the brainstem and its interactions with the trigeminal nerve, a major pain pathway. Imbalances in brain chemicals, including serotonin — which regulates pain— also may be involved. Serotonin levels drop during migraine attacks. This may trigger your trigeminal system to release of neuropeptides, which travel to your brain's covering causing headache.
Answered 8/23/2017
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