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A member asked:

My uncle was prescribed tramadol and cyclobenzaprine he has had memory loss confusion and at times talks very fast and talks about things that have not happened but he thinks have happened could he have serotonin syndrome?

2 doctor answers5 doctors weighed in
Dr. Pamela Pappas
Psychiatry 43 years experience
Drug interactions: Cyclobenzaprine (flexeril) and tramadol (ultram) are both metabolized by the same liver enzyme system, and the combination could result in higher levels of both than intended. Ultram also weakly inhibits serotonin reuptake . . . Serotonin syndrome is possible but should be accompanied by additional features. Seizure threshold can be lower with this combination. Either drug could produce his sx.
Dr. Maureen Nash
Geriatric Psychiatry 25 years experience
Many possibilities: The list of possible explanations range from illness he is taking these medicines for to combining these medicines plus or minus alcohol or other drugs as well as unrelated problems. It sounds like a thorough physical and psychiatric exam are indicated. The risk for serotonin syndrome increases significantly when someone is on at least 3 serotonergic medications.
Last updated Mar 1, 2015

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