What is the best treatment for severe depression?

Depends on history: Response to previous treatments during episodes of depression is a good guide as is family history. Depression that is not responsive to any medications can be lifted by electroconvulsive therapy and other procedures such as deep brain stimulation. Severe depression should be closely monitored by a psychiatrist, who can provide referrals for procedures if needed.

No one best tx.: Your Dr can assess for mood disorder & causative underlying medical conditions. Talking therapy (Cognitive Behavioral Therapy or insight oriented psychotherapy) is allows for lasting change. Psychiatric meds may be indicated. Don't isolate. Spend time w people. Use your support system. Get out. Get at least 8 hrs of sleep/ night & eat healthfully. Daily aerobic physical activity is a big +. Try>