What are the symptoms of sickle cell anaemia?

Many.: Basically, sickle cell disease causes disturbance of the blood vessels, typically smaller vessels. Over time, this can cause many problems. Painful episodes, eye problems, lung problems (similar to pneumonia), strokes, decreased spleen function (which can cause severe infections), kidney problems, and other problems. Sickle cell disease is not the same in all people. Some have milder symptoms.