Can anti seizure medications cause cirrhosis of the liver?

Yes: Some anti-epileptic medications can be toxic to liver and over time can cause liver damage and cirrhosis. This is one of the reasons why physicians obtain bloodwork to monitor drug effects. Some anti-epleptic drugs are more hepatotoxic than others.

Unusual: Many anti-seizure medications are metabolized by the liver. As a result, some may cause liver damage. Fortunately, this is not a common occurrence. Some people with pre-existing liver disease, or certain genetics which affects their ability to process these medications may be more susceptible. Mostly this is a dose related problem, but not always. Close monitoring of the liver is important.