A member asked:

Controversy surrounds those patients with a suppressed tsh. isn't it true that when a hypothyroid patient starts taking exogenous th, a negative feedback system reduces the pituitary gland's output of tsh. this decreases the thyroid gland's output of en

A doctor has provided 1 answer

Endo feedback: With primary hypothyroidism, TSH is elevated in an effort to push the thyroid gland to make more thyroxine. Treatment with levothyroxine indeed signals the pituitary to reduce TSH output. Secondary is when either/or pituitary +/- hypothalamus is damaged but unable to produce tsh. Then, thyroxine levels drop but the pituitary can't respond. Tsh can't monitor treatment but free T4 levels can.

Answered 1/15/2015

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