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A member asked:
What does "fairly prominent nuclear pleomorphism" in a retrocardiac paraganglioma mean?
4 doctors weighed in across 2 answers
Pathology describes: What is seen under the microscope, human cells have nuclei, where the dna is stored on chromosomes, and cytoplasm, where the cellular work is carried out. Tumors may have more or fewer chromosome, tend to actively reproduce and divide , so theirsizes and shape vary. This underlies the characterization of differentiation. More mitoses, varying size conveys "more malignant" behavior theoretically.
Answered 9/15/2012
5.6k views
Nothing: Paraganglioma nearly always have nuclear pleomorphism. This feature is part of being a neuroendocrine tumor type.
Answered 9/8/2019
5.6k views
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