Safe but...: The concept of safety is relative. Mycolog cream will not affect the intercourse, but will most likely not make it pleasant for both you and your partner. Traces of cream will get on his penis and in case of oral sex in his mouth or in your mouth if his penis is smeared with it. I just don't think it's going to be an experience you will look forward to in the future.
Answered 4/22/2015
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