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A 46-year-old member asked:

Is it dangerous to mix alcohol and septra (sulfamethoxazole and trimethoprim)?

2 doctor answers4 doctors weighed in
Dr. Kevin Passer
36 years experience
Maybe: It may not be dangerous from the standpoint of a serious, adverse reaction, however, septra (sulfamethoxazole and trimethoprim) (also known as bactrim) which is an antibiotic can be made less effective if alcohol is consumed while the person is receiving it. I would check with the doctor who prescribed the septra (sulfamethoxazole and trimethoprim).
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Dr. Alan Ali
Dr. Alan Ali commented
Psychiatry 33 years experience
Effectiveness is reduced due to missed dose as result of vomiting the dose of Septra, when taken with alcohol.
Sep 12, 2012
Dr. Alan Ali
Dr. Alan Alianswered
Psychiatry 33 years experience
Alcohol/Bactrim: It is a dangerous combination, not just with alcohol but also with cough medicines & mouthwashes containing alcohol. Alcohol can intensify the negative side-effects of septra, (sulfamethoxazole and trimethoprim) causing headaches, nausea, vomiting, shortness of breath & rapid heart beats, with vomiting leading to dehydration & loss of the antibiotic effect due to missed dose.
Created for people with ongoing healthcare needs but benefits everyone.

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Last updated Apr 24, 2021
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