My wife suffering knee joint problem, age42, advise for replacement, latest advancement?

Not really: Joint replacement studies take many years to perform and it is difficult to know long term outcomes. We always believe that the newest thing is better, but it is difficult to prove. For knee replacements in younger patients, there have not been any proven significant advances. There are new.

Options: At a young age you need a proper diagnosis before you make a permanent change to your knee joint with a replacement. If you do have one it is even more important to have it installed as close to perfect as possible. That is the main factor for a good long term outcome. Definately look into makoplasty robotic partial knee replacement before moving ahead with total knee at her age. Send x-rays.

Ouch!: 42 is very young for a tka. May be indicated though. Things to try to delay are: weight loss; glucosamine/chondrotin; viscoelastic and/or steroid injections; nsaid's. Also, partial vs total replacement? Have very experienced surgeon. Advances for uncemented, mis or custom knee blocks with long lasting polyethelene inserts. Good luck.