No connection.: As a neurologist, there is no link between pituitary -hypothalamic dysfunction and methadone. Methadone is an opioid with nmda stimulating actions, neither of which chemical pathways at doses which do not lead to profound stupor or coma, will cause hpa (hypothalamic-pituitary axis) dysfunction. Endocrinologists are best equipped to answer questions about hypogonadism such as low-t.
Answered 6/28/2014
5.6k views
See below: Methadone is absolutely the cause of the low testosterone due to hypothalamic dysfunction. It leads to the persistence of pain, fatigue, depression and poor sense of well being. It can only be treated by weaning or testosterone replacement.
Answered 5/8/2016
5.6k views
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