A 36-year-old member asked:
is tetralogy of fallot a hereditary problem?
1 doctor answer
Dr. Nikolaos Zacharias answered
25 years experience Maternal-Fetal Medicine
Not typically.: Most cases are isolated and sporadic. It accounts for 5-10% of all congenital heart defects. 15% of tof cases are part of known genetic syndromes (down, digeorge, alagille, phenylketonuria) or associations (charge/vacterl) and some are linked to poorly controlled preconceptional maternal diabetes mellitus. Recurrence risk: 2.5% with one prior affected child, 8% with two. Folic acid may prevent it!
Answered on Nov 18, 2015
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