How can chemotherapy affect metastatic cancer of the liver?

Yes: Chemotherapy is routinely used to treat colon cancer metastatic to the liver.

Cancer in the Liver: Cancer that has spread (metastasis) to the liver is still considered the same cancer as the original one. Primary cancers of the lung, breast, colon and rectum can certainly spread to the liver. Chemotherapy can be effective in treating metastases to the liver but other kinds of treatments (surgery, internal radiation, radiofrequency ablation, embolization with chemotherapy) are also available.