Does a double lung transplant completely eliminate lung problems for cystic fibrosis patients?

It should: Cystic fibrosis is a genetic condition causing significant lung dysfunction. A double lung transplantation replaces the native lungs with supposedly normal lungs, eliminating the problem, but replacing it with problems directly related to transplanted lungs, i.e. Chronic rejection or bronchiolitis obliterans.

CF Transplantation: A double lung transplantation for CF does treat CF lung disease, but the patient still has cystic fibrosis, affecting other organs, including the GI tract and sinuses. There are a number of lung problems that can develop after surgery, including infections. The treatment regimen will be very different from your usual CF regimen and will include medications to prevent rejection.