What is the most effective weight loss pill available?

Can't rely on a pill: Over-the-counter diet pills decrease one's appetite a bit (they are related to stimulants). A person's desire to eat can be much stronger that a diet pill's power to decrease his appetite, so he will likely continue to eat too many calories. Also, diet pills don't increase one's desire to exercise. If something as simple as a diet pill actually worked, we would not have so much obesity in america.