Is it possible to live without a spleen?

Yes: The spleen plays an important role in infection prevention as it can filter out certain encapsulated bacteria. Accordingly, after splenectomy it is important to get immunized against these bacteria.

Yes: Many people have lost their spleen due to trauma or surgery to treat low platelets. Sickle-cell disease often kills the spleen over time. Some people have an "accessory spleen" that will then grow. Other parts of the body can take over some of the spleen's function. You will need to be vaccinated against encapsulated organisms as the spleen fights these.