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A member asked:
Can percocet interfere with serotonin in the brain and bring on full blown depression in a person with depression history.?
A doctor has provided 1 answer
Yes: Yes, opiate medication use, which is one of the ingredients in Percocet can cause depression, and someone with a past history of depression would be at higher risk for this side effect. Further, sometimes antidepressant medication doesn't work as well to treat a depression brought on by opiate med use until the person reduces or stops using the opiate medication.
Answered 9/6/2015
5.7k views
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