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Flushing, NY
A 43-year-old male asked:

Can percocet interfere with serotonin in the brain and bring on full blown depression in a person with depression history.?

1 doctor answer9 doctors weighed in
Dr. Jeff Jacobs
Child Psychiatry 24 years experience
Yes: Yes, opiate medication use, which is one of the ingredients in Percocet can cause depression, and someone with a past history of depression would be at higher risk for this side effect. Further, sometimes antidepressant medication doesn't work as well to treat a depression brought on by opiate med use until the person reduces or stops using the opiate medication.
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Last updated Sep 6, 2015

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